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Dr. HariOm Singh
Name : Dr. HariOm Singh
Designation : Scientist D
Division : Molecular Biology
Email ID : [email protected]/[email protected]
Area Of Interest : Host Genetics, Pharmacogenomics
Completed and Ongoing Projects
Awards and Honours
  • NIH Office of AIDS Research (OAR) Training Fellowship Award, 2018
  • Young Scientist Award- ICIPMBS-2018
Work Experience

Work Experience

Work Experience

Post Held

Employer

Duration

From

To

Research & Development

 Scientist D

 ICMR-NARI, GOI

October 2019

Till date

Research & Development

NIH-Fellow

State University of New York, USA

March 2019

October 2019

Research & Development

 Scientist C

 ICMR- NARI, GOI

 

 October 2015

February 2019

Research & Development

Scientist B

ICMR- NARI, GOI

 

August 2010

September 2015

Research & Development

ICMR-Research Associate

SGPGIMS, Lko

Feb 2010

July 2010

List of Grant Recieved

Ongoing and completed projects  (List of Grant Received )

Sr.No.

Title of Project

Duration

Funding Agency

Role

Ongoing/completed

1

Comparative analysis of genetic variation and expression of Apo family of lipoprotein, lipid metabolizing enzyme and transporter genes between HIV-associated lipodystrophy patients taking PIs with and without the history of receiving stavudine or zidovudine based regimen

2021-2024

ICMR

 

P.I

Initiated

2

Comparative analysis of Host factors among individuals with novel Coronavirus infection

2021-2024

ICMR

 

P.I

Initiated

3

Comparative analysis of Host factors and Clinico-Radiological features among different stages of SARS-CO-2 infection

2021-2024

To be submitted

 

P.I

To be initiated

3

Study of genetic variation and expression of drug metabolizing enzyme, transporter and Apolipoprotein genes between TDF and TAF -related renal dysfunction among patients of HIV - hepatitis B co-infection

2021-2024

Intramural

P.I

Initiated

4

Genetic variation of Drug metabolizing enzyme genes in HIV-infected individuals on EFV 600 mg containing ART

2021-2024

Intramural

P.I

To be initiated

5

Comparative analysis of expression pattern of Apo family of lipoprotein genes among patients with HIV-associated lipodystrophy from Indian and United States HIV patient cohorts

March 2019 to October 2019

NIH-CRDF-USA

 

P.I

Completed

6

Genetic Variants of Matrix Metalloproteinase Enzyme in HIV-related Neurological disease

2013 -2017

ICMR

 

P.I

Completed

7

Genetic susceptibility of AIDS Restriction genes in HIV infected Individuals naive to ART

2014 -2018

ICMR-NARI Intramural

P.I

Completed

8

Genetic susceptibility of Drug Metabolizing Enzyme genes in Patients with ARV- associated Hepatotoxicity

2014 -2018

ICMR-NARI Intramural

P.I

Completed

Conference/Training/Workshop Attended

Conferences/Trainings/Workshops Attended

  • 1) Revolutionize cell line development & Engineering to improve product quality, reduce time lines & increase titers at Park  central Hotel, San Francisco, CA, June 18-20,2019

    2) Structure Biology Related to HIV/AIDS at NIH on June 27-28, 2019 at Natcher conference center Bethesda, Maryland, US

    3) Meeting on Microbiome at Cold Spring Harbor Laboratory, New York, July 18-21,2019

 

Number of Publications : 45
List of Publications

Number of publications

 Published Papers: 47, Book chapter: 1, Sequence Submitted: 1

List of publications

  1. Singh H, Jakhar K, Nema V, Krishnaraj A, Choudhari R. Effect of miRNAs, Proinflammatory Cytokines and ACE2 in COVID-19 Pathophysiology. Coronaviruses, 2021, 2,1-0
  2. Singh H, Jadhav S, Chauware V. Impact of MBL-2 coding region polymorphism on modulation of HAND and HIV-1 acquisition. Microb Pathog. 2021
  3. Arif Khan, Tashfeen, Muhammad Bilal, Singh H. Microbiota, probiotics and respiratory infections: the three musketeers can tip off potential management of COVID-19" has been reviewed. American Journal of Translational Research (AJTR0136096R1),2021
  4. Khan AA, Sirsat AT, Singh H, Cash P. Microbiota and cancer: current understanding and mechanistic implications. Clin Transl Oncol. 2021 Aug 13:1-10.
  5. Singh H, Singh A, Khan AA, Gupta Immune mediating molecules and pathogenesis of COVID-19-associated neurological disease. Microb Pathog. Vol 158, Sepr 2021,
  6. Singh H, Chauware V, Jakhar K. Comparative Occurrence of TLR3 and TLR7 Polymorphisms among healthy individual of various population. Current Pharmacogenomics and Personalized Medicine. Volume 182021.
  7. Singh H Lata Occurrence of DAT1 (VNTR) Polymorphism in Individuals with HIV infection. Current Pharmacogenomics and Personalized Medicine. 2021, DOI10.2174/1875692118666210421104202
  8. Singh H, Choudhari R. Role of Host Genetic Factors in Patients with Astrocytomas. Biotechnol Biomater 2021, 2:1
  9. Singh H, Choudhari R. Novel Drug Delivery Formulations of Herbal Bioactive Molecules. Indian Journal of Novel Drug Delivery 13(1), Jan-Mar, 2021, 10-17
  10. Singh H, Choudhari R, Nema V, Khan AA. ACE2 and TMPRSS2 polymorphisms in various diseases with special reference to its impact on COVID-19 disease. Microb Pathog. 2021 Jan; 150:104621.
  11. Singh H, Lata S, Choudhari R, Dhole T.N. Prevalence of ABCC3 1767G/A polymorphism among patients with antiretroviral -associated hepatotoxicity. Mol Genet Genomic Med. 2020;00:e1124
  12. Singh H, Samani D, Aggarwal S. TLR7 polymorphism (rs179008 and rs179009) in HIV infected individual naïve to ART. Mediators of Inflammation. Apr 2020; 21,
  13. Singh H, Nain S, Krishnaraj A, Lata S, Dhole TN. Genetic variation of matrix metalloproteinase enzyme in HIV-associated neurocognitive disorder. 2019 May 25; 698:41-49.
  14. HariOm Singh, Sushma Jadhav, Dharmesh Samani and Sumitra Nain. Tissue Inhibitor of Metalloproteinase-2 polymorphisms and Risk for HIV-associated neurocognitive disorder. Mediators of Inflammation 2019, May 28, 10 pages, 2019.
  15. Singh HO, Maan HS, Dhole TN. Gene Silencing: A Novel Approach and Suppression of HIV-1 Gene. J Mol Genet Med 2019 April 22: 13: 420
  16. Singh H, Lata S, Dhole TN, Gangakhedkar RR. Occurrence of CYP2B6 516G>T polymorphism in patients with ARV-associated hepatotoxicity. Mol Genet Genomic Med. 2019 Apr;7(4):e00598
  17. Hari Om Singh, Sushma Jadhav, Dharmesh Samani, T.N Dhole. Polymorphisms in miRNAs gene (146a, 149, 196a) and susceptibility to ARV-associated hepatotoxicity. Current Genomics, 2019 Feb; 20(2):134-150.
  18. HariOm Singh, Dharmesh Samani, R.R.Gangakhedkar. Interleukin-10 polymorphisms and Susceptibility to ARV associated hepatotoxicity. Microbial Pathogenesis 2019 May 20; 133:103544.
  19. Singh H, Nambiar N, Samani D, Gangakhedkar RR. Occurrence of Interleukin-2 (330 G/T) Promoter Polymorphism in ARV associated hepatotoxicity. Curr Mol Med. 2019 Apr 10. doi: 10.2174/1566524019666190411093451.
  20. Singh H, Gangakhedkar RR. Occurrence of APOBEC3G variations in West Indian HIV patients. Microb Pathog. 2018 Jun 2; 121:325-330.
  21. Singh H, Lata S, Gangakhedkar RR. Prevalence of CYP2D6*4 1934G/A Polymorphism in Western Indian HIV patients. APMIS. 2018 Nov;126(11):842-851
  22. Singh H, Samani D, Nema V, Ghate M.V, and Gangakhedkar R,R. IL-1RN and IL-1β Polymorphism and ARV-Associated Hepatotoxicity. Mediators of Inflammation. 2018 Apr 8;2018:4398150
  23. Singh H, Samani D, Nambiar N, Ghate MV, Gangakhedkar RR. Effect of matrix metalloproteinase-21 (572C/T) polymorphism on HIV-associated neurocognitive disorder. 2018 Apr; 126(4):329-336.
  24. Singh H, Samani D, Nambiar N, Ghate MV, Gangakhedkar RR.Prevalence of MMP-8 gene polymorphisms in HIV-infected individuals and its association with HIV-associated neurocognitive disorder. 2018 Mar 10;646:83-90
  25. Singh H and Nain S. Matrix Metalloproteinases Enzyme and Risk for HIV-Associated Neurocognitive Disorders. Austin Journal of HIV/AIDS Research. January 30, 2018
  26. Singh H, Samani D, Ghate MV, Gangakhedkar RR. Impact of cellular restriction gene (TRIM5α, BST-2) polymorphisms on the acquisition of HIV-1 and disease progression. J Gene Med. 2018 Feb; 20(2-3):e3004.
  27. Singh H, Lata S, Nema V, Samani D, Ghate M, Gangakhedkar RR. CYP1A1m1 and CYP2C9*2 and *3 polymorphism and risk to develop ARV-associated hepatotoxicity and its severity. 2017 Jun; 125(6):523-535.
  28. Singh H, Samani D, Ghate MV, Gangakhedkar R,R. Impact of cellular restriction gene (TRIM5α, BST-2) polymorphisms on the acquisition of HIV-1 and disease progression. J Gene Med. 2017 Dec 28. doi: 10.1002/jgm.3004
  29. Singh H, Marathe S D, Nain S, Samani D, Nema V, Ghate M V, Gangakhedkar R . Promoter polymorphism MMP-1 (-1607 2G/1G) and MMP-3 (-1612 5A/6A) in development of HAND and modulation of pathogenesis of HAND. J Biosci. 2017 September, 42, 481–490
  30. Singh HO, Lata S, Angadi M, Bapat S, Pawar J, Nema V, Ghate MV, Sahay S, Gangakhedkar RR. Impact of GSTM1, GSTT1 and GSTP1 gene polymorphism and risk of ARV-associated hepatotoxicity in HIV-infected individuals and its modulation. Pharmacogenomics J. 2017 Jan; 17(1):53-60.
  31. Vijay Nema, Hari Om Singh. Host Pharmacogenomics: to be Remembered while Planning a Cure for HIV. BAOJ Hiv 2017 3:1
  32. Singh H, Marathe S, D, Nain S, Nema V, Ghate M. V, Gangakhedkar R, R. Impact of variants of MMP-7(-181A>G) gene in susceptibility to development of HAND and its severity. APMIS. 2016 Nov;124(11):966-972
  33. HariOm Singh, Shruti D Marathe, Vijay Nema, Manisha Ghate, Raman R.Gangakhedkar. Genetic variation of MMP-2 & MMP-9 polymorphism in susceptibility to development of HAND and its severity. J Gene Med. 2016 Sep; 18(9):250-7.
  34. HariOm Singh, Shruti D Marathe, Sumitra Nain, Vijay Nema, Manisha V Ghate, Raman.R.Gangakhedkar. APOBEC3B deletion impacts on susceptibility to acquire HIV-1 and its advancement among Individuals in Western India. 2016 Oct;124(10):881-7
  35. HariOm Singh, Shruti Marathe, Sumitra Nain, Mansa Angadi, Shradha Bapat, Jyoti Pawar,Vijay Nema, Manisha Ghate, Seema Sahay, R.R.Gangakhedkar .Coding region variant

186H/R in Exon 4 of APOBEC3G among individuals of Western India. APMIS. 2016 May;124(5):401-5

  1. Supriya D. Mahajan*,Asmita Gaekwad, Jyoti Pawar, Srikanth Tripathy, Manisha Ghate, Jayanta Bhattacharya, HariOm Singh, Stanley A. Schwartz, Ramesh Paranjape and Raman Gangakhedkar. Cardiac Morbidity in an HIV-1 Lipodystrophy Patient Cohort Expressing the TNF-α-238 G/A Single Nucleotide Gene Polymorphism. Curr HIV Res. 2015; 13(2):98-108.
  2. Sumitra Nain,* Anu Sharma, Hariom Singh, Sarvesh Paliwal. Recent Advances in use of Semicarbazones as Anticonvulsant Agents: A Review. Biomed. Ther. Sci. 2015, 2(1), 1-7
  3. Hari Om Singh, Amita Singh, TN Dhole and Sumitra Nain. Effect of Ormeloxifene for Management of Dysfunctional Uterine Bleeding. Biochem Physiol 2015, 4:3
  4. Hari Om Singh, Amita Singh, TN Dhole and Sumitra Nain. Factor associated to Bacterial Vaginosis in Nonpregnant women of North Indian population. J Biotechnol Biomater 2015, 5:3
  5. Hari OS, Sonali G and Sumitra N. Awareness and Trends of Blood Cholesterol and Susceptibility to Develop Heart Disease. Adv Genet Eng 2015, 4:3
  6. Gangwar R, Mittal B. Srivastava Shuti, Singh H, Mittal R Genetic Variants of DNA Repair Gene XPC Modulating Susceptibility to Cervical Cancer in North India. Onco Res 2010; 18:1-100
  7. Singh H, Jain M, Mittal B. TGF-β1 (-509C/T) Gene Polymorphisms and Susceptibility to Cervical Cancer.Onco Res. 2009; 18(1):41-5.
  8. Singh H, Sachan R, Devi S, Pandey S N, Mittal B. Association of GSTM1, GSTT1 and GSTM3 gene polymorphisms and susceptibility to cervical cancer in North Indian population. Am J Obstet Gynecol. 2008; 198:303-6.
  9. Singh H, Sachan R, Geol H, Mittal B. Genetic Variations in Interleukin-1 receptor antagonist and Interleukin-1β genes and cervical cancer. British J. Obstetrics and Gynecology 2008; 115:633–638.
  10. Singh H, Sachan R, Jain M, Mittal B. CCR5-Δ32 Polymorphism and Susceptibility to Cervical Cancer: Association with Early Stage of Cervical Cancer. Oncol Res. 2008; 17:87-91.
  11. Singh H, Jain M, Sachan R, Mittal B. TNF-α (-308G/A) and IL-10(-819C/T) Promoter Polymorphisms and Risk of Cervical Cancer. J Gynecological Cancer 2009; 19(7):1190-1194.
  12. Singh H, Jain M, Mittal B. MMP-7(-181 A/G) Gene Polymorphisms and Risk for Cervical Cancer. Gynecol Oncol. 2008; 110:71-5.

Book chapter

  1. Sumitra Nain, Garima Mathur,Pragati Karana, HariOm Singh. Physical and Chemical Properties of Nanobiomaterials. Pharmaceutical Technology (Nanobiomaterials
    Applications in Drug Delivery) Apple Academic Press. Mar, 2017

Gene sequence

Jagtap,D.D., Gupte,D.S., Thakar,M.R., Singh,H.O., Pandey,S., C,S.K. and Paranjape,R.S. Molecular characterization of tetherin/BST-2 gene promoter in  Indian HIV infected long term non progressors. GenBank-2014