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Dr. Swarali Nitin Kurle
Name : Dr. Swarali Nitin Kurle
Designation : Scientist C
Division : HIV Drug Resistance Laboratory
DOB :
Email ID : skurle@nariindia.org
Area Of Interest : HIV drug resistance, Phylogenetic analysis, Immunology
Awards and Honours
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Work Experience

Work Experience

Post Held

Employer

Duration

Scientist C

ICMR-NARI, Pune

September 2016-Till date

Scientist B

ICMR-NARI, Pune

May 2013- August 2016

 

List of Grant Recieved

List of grants received

Sr.No.

Title of Project

Duration

Funding Agency

Role

1

HIV drug resistance surveys to assess the pre treatment and acquired drug resistance among patients before initiating; and after receiving antiretroviral therapy at 12 months & 48 months in India

1 year

NACO

 

 

PI

2

Development of a National HIV Drug Resistance Database by Generating and Utilizing Clinical, Genotypic and Phenotypic Characterization Data of the Prevalent Drug Resistant Strains of Indian HIV-1 Clade C

3 years

ICMR

 

 

Investigator

3

Antibody-Dependent Cellular Cytotoxicity (ADCC): a new frontier in vaccine

3 years

DBT

 

 

Co-investigator

4

Effectiveness of antiretroviral therapy in free ART centres in Pune city

3 months

WHO/ NACO

 

Co-investigator

5

Evaluation of sensitivity of In-house drug resistance assay using the Dried Blood Spots (DBS) from HIV infected patients with or without ART

3 months

WHO

 

 

Co-investigator

6

Comparative evaluation of ViveST and DBS specimens for HIV-1 Drug resistance genotyping

6 months

WHO

 

 

Investigator

7

A Randomized Trial to Evaluate the Effectiveness of Antiretroviral Therapy plus HIV Primary Care versus HIV Primary Care Alone to Prevent the Sexual Transmission of HIV-1 in Serodiscordant Couples: (HPTN 052)

10 years

WHO

 

 

Coinvestigator for Drug resistance testing

8

Cohorts for HIV Resistance and Progression in Indian Children and Adults (CoHRPICA)

5 years

DBT-ICMR

 

Investigator

7

Generation of polyclonal antibodies mediating antibody dependent cell

mediated cytotoxicity against HIV-1

3 years

DBT

 

Investigator

8

Study title: Evaluation of “Xpert HIV-1 Qual testing kits” for diagnosis of HIV-1 infection in infants born to HIV infected mothers

15 months

WHO

PI

9

Epidemiological and laboratory investigation of HIV outbreak in rural Uttar Pradesh, India: a case control study

1 year

NACO

Co-investigator

10

Analysis of HIV genotypes in Transgenders (TG) population from India

1 year

ICMR-intramural

PI

11

Assessing the Anti Retroviral Treatment (ART) drug resistance in HIV infected infants

6  months

ICMR-intramural

PI

12

Evaluation of Dried Blood Specimens (DBS) collected on filter papers from three manufacturers for detection of HIV-1 infection using Abbott real time HIV-1 qualitative assay for their potential applicability in the National EID program

1 year

NACO

PI

Conference/Training/Workshop Attended

Conferences/Trainings/Workshops Attended

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Number of Publications : 15
List of Publications

List of Publications

  1. Indian Long-term NonProgressors Show Broad ADCC Responses with Preferential Recognition of V3 Region of Envelope and a Region from Tat Protein. Front. Immunol. 8:5.
  2. Case reports with Phylodynamic Evidence of Non-vertical HIV Transmission in Children, India. 2016. Submitted to Pediatrics. Provisionally Accepted.
  3. Cross Sectional Study of Virological Failure and Multi-Nucleoside Reverse Transcriptase Inhibitor Resistance at 12 months of Antiretroviral Therapy in Western India. Medicine, 2016 Sep;95(37):e4886.
  4. Karade S, Patil AA, Ghate M, Kulkarni SS, Kurle SN, Risbud AR, Rewari BB, Gangakhedkar RR (2016). Limited HIV Pretreatment Drug Resistance Among Adults Attending Free Antiretroviral Therapy Clinic of Pune, India. AIDS Res Hum Retroviruses. 2016 Apr;32(4):377-80. doi: 10.1089/AID.2015.0277. Epub 2016 Jan 7.
  5. Outcome of patients on second line antiretroviral therapy under programmatic condition in India. BMC Infect Dis. 2015 Nov 14;15:517.
  6. Near Full-Length Genomic Characterization of a Novel CRF 01_AE/C Recombinant from Western India. AIDS Res. and Hum. Retro.Volume 31, Number 00, 2015.
  7. Differential modulation of phenotypic composition of HIV infected and uninfected PBMCs during cryopreservation. Journal of Immunoassay & Immunochemistry; 2013, Vol. 34 Issue 4, p333-345.
  8. Safety and immunogenicity of DNA and MVA HIV-1 subtype C vaccine prime-boost regimens: A Phase I trial in HIV-uninfected Indian volunteers. PLoS ONE; 2013, 8(2), e55831.
  9. In vitro sensitization of T cells with DC associated/delivered HIV constructs can induce polyfunctional CTL response, memory T cell response and virus suppression. Viral Immunology 2012, Volume 25, pp 45-54.
  10. Emergence of NNRTI drug resistance mutations after single-dose nevirapine exposure in HIV type 1 subtype C-infected infants in India. AIDS Res Hum Retroviruses. 2007 May;23(5):682-5. PubMed PMID: 17530993.
  11. Srikanth P. Tripathy, Smita S.Kulkarni, Sushama D Jadhav, Kalpana D Agnihotri ,Abhay J Jere, Swarali  N Kurle, Sujit K. Bhattacharya, Khomdon Singh, Sriram P. Tripathy and Ramesh S. Paranjape. Detection of Subtype C and Subtype B HIV-1 Recombinants in India. AIDS Res. and Hum. Retro, February 2005:152-157.
  12. Full-length gag sequences of HIV-1 subtype C recent seroconverters from Pune, India. AIDS Res. and Hum. Retro.2004 Vol.20,No.10,1113-1118.
  13. gp120 sequences from HIV -1 subtype C early seroconverters in India. AIDS Res. and Hum. Retro. 2004 Vol.20,No.8,889-894.
  14. Mother to Child HIV Transmission: NARI Experience”. Proceedings of International Conference on Emerging trends in Haematology & Immunohaematology. Published by Institute of Immunohaematology, Mumbai, 2007, pages 45-50.
  15. Shubhankar S. Ambike, Madhuri R. Thakar, Ajit A. Patil, Raman R. Gangakhedkar, and Swarali N. Kurle. Partial pol Sequences from Drug Naive HIV-2 Infected Individuals from Maharashtra, India. AIDS RESEARCH AND HUMAN RETROVIRUSES Volume 35, Number 5, 2019; pg.505-508