Profile
- Name : DR. SWARALI NITIN KURLE
- Designation : Scientist E
- Division : Basic Immunology & Technology Development
- Email ID : [email protected]
- Area Of Interest : HIV drug resistance, Phylogenetic analysis, Immunology
- Completed and Ongoing Projects
- Awards and Honours
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- Work Experience
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Work Experience
Post Held
Employer
Duration
Scientist C
ICMR - National Institute Of Translation Virology And Aids Research (NITVAR)
September 2016-Till date
Scientist B ICMR - National Institute Of Translation Virology And Aids Research (NITVAR)
May 2013- August 2016 - List of Grant Recieved
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List of Grant Received:
Study Title
Funding Agency
HIV drug resistance surveys to assess the pre-treatment and acquired drug resistance among patients before initiating; and after receiving antiretroviral therapy at 12 months & 48 months in India
NACO
Development of a National HIV Drug Resistance Database by Generating and Utilizing Clinical, Genotypic and Phenotypic Characterization Data of the Prevalent Drug Resistant Strains of Indian HIV-1 Clade C
ICMR
Antibody-Dependent Cellular Cytotoxicity (ADCC): a new frontier in vaccine
DBT
Effectiveness of antiretroviral therapy in free ART centres in Pune city
WHO/ NACO
Evaluation of sensitivity of In-house drug resistance assay using the Dried Blood Spots (DBS) from HIV infected patients with or without ART
WHO
Comparative evaluation of ViveST and DBS specimens for HIV-1 Drug resistance genotyping
WHO
A Randomized Trial to Evaluate the Effectiveness of Antiretroviral Therapy plus HIV Primary Care versus HIV Primary Care Alone to Prevent the Sexual Transmission of HIV-1 in Serodiscordant Couples: (HPTN 052)
WHO
Cohorts for HIV Resistance and Progression in Indian Children and Adults (CoHRPICA)
DBT-ICMR
Generation of polyclonal antibodies mediating antibody dependent cell mediated cytotoxicity against HIV-1
DBT
Study title: Evaluation of “Xpert HIV-1 Qual testing kits” for diagnosis of HIV-1 infection in infants born to HIV infected mothers
WHO
Epidemiological and laboratory investigation of HIV outbreak in rural Uttar Pradesh, India: a case control study
NACO
Analysis of HIV genotypes in Transgenders (TG) population from India
ICMR-intramural
Assessing the Anti-Retroviral Treatment (ART) drug resistance in HIV infected infants
ICMR-intramural
Evaluation of Dried Blood Specimens (DBS) collected on filter papers from three manufacturers for detection of HIV-1 infection using Abbott real time HIV-1 qualitative assay for their potential applicability in the National EID program
NACO
Understanding antiretroviral drug resistance and HIV genotypes among HIV infected female sex workers and people who inject drugs in Mizoram
ICMR-North East Grant
Probing the interaction between SARS-CoV-2 Nsp13 and cellular ALIX protein.
ICMR-intramural
- Conference/Training/Workshop Attended
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Conferences/Trainings/Workshops Attended
- Number of Publications : 15
- List of Publications
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List of Publications:
- Kulkarni A, Kurle S, Shete A, Ghate M, Godbole S, Madhavi V, Kent SJ, Paranjape R, Thakar M. Indian Long-term Non-Progressors Show Broad ADCC Responses with Preferential Recognition of V3 Region of Envelope and a Region from Tat Protein. Front Immunol. 2017 Jan 19;8:5. doi: 10.3389/fimmu.2017.00005. PMID: 28154562; PMCID: PMC5243827.
- Karade SK, Ghate MV, Chaturbhuj DN, Kadam DB, Shankar S, Gaikwad N, Gurav S, Joshi R, Sane SS, Kulkarni SS, Kurle SN, Paranjape RS, Rewari BB, Gangakhedkar RR. Cross-sectional study of virological failure and multinucleoside reverse transcriptase inhibitor resistance at 12 months of antiretroviral therapy in Western India. Medicine (Baltimore). 2016 Sep;95(37):e4886. doi: 10.1097/MD.0000000000004886. PMID: 27631260; PMCID: PMC5402603.
- Karade S, Patil AA, Ghate M, Kulkarni SS, Kurle SN, Risbud AR, Rewari BB, Gangakhedkar RR (2016). Limited HIV Pretreatment Drug Resistance Among Adults Attending Free Antiretroviral Therapy Clinic of Pune, India. AIDS Res Hum Retroviruses. 2016 Apr;32(4):377-80. doi: 10.1089/AID.2015.0277. Epub 2016 Jan 7.
- Chakravarty J, Sundar S, Chourasia A, Singh PN, Kurle S, Tripathy SP, Chaturbhuj DN, Rai M, Agarwal AK, Mishra RN, Paranjape RS. Outcome of patients on second line antiretroviral therapy under programmatic condition in India. BMC Infect Dis. 2015 Nov 14;15:517. doi: 10.1186/s12879-015-1270-8. PMID: 26572102; PMCID: PMC4647630.
- Karade S, Pandey S, Gianchandani S, Kurle SN, Ghate M, Gaikwad NS, Rewari BB, Gangakhedkar RR. Near Full-Length Genomic Characterization of a Novel CRF 01_AE/C Recombinant from Western India. AIDS Res Hum Retroviruses. 2015 Dec;31(12):1269-73. doi: 10.1089/aid.2015.0228. Epub 2015 Aug 31. PMID: 26323027.
- Shete A, Jayawant P, Thakar M, Kurle S, Singh DP, Paranjape RS. Differential modulation of phenotypic composition of HIV-infected and -uninfected PBMCs during cryopreservation. J Immunoassay Immunochem. 2013;34(4):333-45. doi: 10.1080/15321819.2012.741087. PMID: 23859784.
- Mehendale S, Thakar M, Sahay S, Kumar M, Shete A, Sathyamurthi P, Verma A, Kurle S, Shrotri A, Gilmour J, Goyal R, Dally L, Sayeed E, Zachariah D, Ackland J, Kochhar S, Cox JH, Excler JL, Kumaraswami V, Paranjape R, Ramanathan VD. Safety and immunogenicity of DNA and MVA HIV-1 subtype C vaccine prime-boost regimens: a phase I randomised Trial in HIV-uninfected Indian volunteers. PLoS One. 2013;8(2):e55831. doi: 10.1371/journal.pone.0055831. Epub 2013 Feb 13. PMID: 23418465; PMCID: PMC3572184.
- Kurle S, Thakar M, Shete A, Paranjape R. In vitro sensitization of T cells with DC-associated/delivered HIV constructs can induce a polyfunctional CTL response, memory T-cell response, and virus suppression. Viral Immunol. 2012 Feb;25(1):45-54. doi: 10.1089/vim.2011.0055. Epub 2012 Jan 10. PMID: 22233251; PMCID: PMC3271377.
- Emergence of NNRTI drug resistance mutations after single-dose nevirapine exposure in HIV type 1 subtype C-infected infants in India. AIDS Res Hum Retroviruses. 2007 May;23(5):682-5. PubMed PMID: 17530993.
- Srikanth P. Tripathy, Smita S.Kulkarni, Sushama D Jadhav, Kalpana D Agnihotri ,Abhay J Jere, Swarali N Kurle, Sujit K. Bhattacharya, Khomdon Singh, Sriram P. Tripathy and Ramesh S. Paranjape. Detection of Subtype C and Subtype B HIV-1 Recombinants in India. AIDS Res. and Hum. Retro, February 2005:152-157.
- Kurle S, Tripathy S, Jadhav S, Agnihotri K, Paranjape R. Full-length gag sequences of HIV type 1 subtype C recent seroconverters from Pune, India. AIDS Res Hum Retroviruses. 2004 Oct;20(10):1113-8. doi: 10.1089/aid.2004.20.1113. PMID: 15585103.
- Kalpana A, Srikanth T, Abhay J, Sushama J, Swarali K, Ramesh P. gp120 sequences from HIV type 1 subtype C early seroconverters in India. AIDS Res Hum Retroviruses. 2004 Aug;20(8):889-94. doi: 10.1089/0889222041725217. PMID: 15320993.
- “Mother to Child HIV Transmission: NARI Experience”. Proceedings of International Conference on Emerging trends in Haematology & Immunohaematology. Published by Institute of Immunohaematology, Mumbai, 2007, pages 45-50.
- Shubhankar S. Ambike, Madhuri R. Thakar, Ajit A. Patil, Raman R. Gangakhedkar, and Swarali N. Kurle. Partial pol Sequences from Drug Naive HIV-2 Infected Individuals from Maharashtra, India. AIDS RESEARCH AND HUMAN RETROVIRUSES Volume 35, Number 5, 2019; pg.505-508.
- Patil S, Rao A, Pathak P, Kurle S, Mane A, Nirmalkar A, et al. (2020) Unsterile injection equipment associated with HIV outbreak and an extremely high prevalence of HCV—A case-control investigation from Unnao, India. PLoS ONE 15(12): e0243534.
- Sannoong Hu, Ajit Patil, Devidas Chaturbhuj, Swarali Kurle. Analysis of HIV-1 Integrase gene by applying an easy cost-effective in-house assay using plasma and Dried Blood Spot (DBS) specimens. BMC Infectious Diseases 2020, 20(Suppl 1):324
- Patil A, Elwitigala JP, Rajapaksa L, Gangakhedkar R, Chaturbhuj D, Pendse R, et al. (2020) HIV-1 polgene diversity and molecular dating of subtype C from Sri Lanka. PLoS ONE 15(6): e0234133.
- Kulkarni, Prasad S. and Padmapriyadarshini, Chandrasekaran and Vekemans, Johan and Bavdekar, Ashish and Gupta, Madhu and Kulkarni, Praveen and Garg, B. S. and Gogtay, Nithya J. and Tambe, Muralidhar and Lalwani, Sanjay and Singh, Kiranjit and Munshi, Renuka and Meshram, Sushant and Selvavinayagam, T. S. and Pandey, Krishna and Bhimarasetty, Devi Madhavi and Ramakrishnan, S. R. and Bhamare, Chetanraj and Dharmadhikari, Abhijeet and Vadakkedath, Rajeev and Bonhomme, Cyrille J. and Thakar, Madhuri and Kurle, Swarali N. and Kelly, Elizabeth J. and Gautam, Manish and Gupta, Nivedita and Panda, Samiran and Bhargava, Balram and Shaligram, Umesh and Kapse, Dhananjay and Gunale, Bhagwat and Group, COVISHIELD Study, A Phase 2/3, Observer-Blind, Randomised, Controlled Study to Assess the Safety and Immunogenicity of SII-ChAdOx1 nCOV-19 (COVID-19 Vaccine) in Adults in India.
